Pawel Goral, Cold War Rivalry and the Perception of the American West

In his first monograph, Cold War Rivalry and the Perception of the American West, Pawel Goral, History lecturer at the University of Texas, Arlington, employs the myth of the American West as a critical lens to address the fascinating, albeit complex, theme of cultural memory and identity-building in Cold-War-divided-Germany. Goral’s thesis argues how the two spheres of political influence shaped opposing views of the Western myth, and how each block respectively deployed it to accommodate their own nationalistic needs. This contributed, the author claims, to fill the cultural void left in the aftermath of the Third Reich, as well as to the formation of a unified sense of Germanness after the fall of the Iron Curtain

Bernice M. Murphy, The Rural Gothic in American Popular Culture, Backwoods Horror and Terror in the Wildernes

Bernice M. Murphy, popular literature lecturer at Dublin’s Trinity College, opens her wide-ranging survey of The Rural Gothic in American Popular Culture with a telling remark: “it is no coincidence that when American authors and film-makers fantasise about the end of civilisation as they know it, they so often produce narratives which unconsciously evoke the beginnings of European settlement”(2). Indeed, a body of scholarship in gothic fiction (Fiedler, Goddu, Lloyd-Smith) concurs in tracing back the trope of the inherent monstrosity and grotesqueness of the American wilderness and its inhabitants to the literary production that stemmed out of the earliest days of the New World’s conquest, ranging from travellers’ memoirs to captivity tales and puritan novels

Rough riders in the cradle of civilization : Buffalo Bill’s Wild West Show in Italy and the challenge of American cultural scarcity at the fin-de-siècle

Comparisons with European culture have often generated feelings of discomfort and anxiety in the United States. Since the age of the Enlightenment, American culture has been associated with a desert or wasteland. This conceptual inclination persisted well into the 19th century − when several American writers picked up on the perceived dearth of culture that the American intellectual landscape offered − until the Gilded Age, when the United States powerfully asserted itself as an economic and industrial power. Cultural affirmation remained, therefore, the last frontier for America to conquer. In this context, the soft power operated by Buffalo Bill Cody’s Wild West show in Europe proved to be a tremendous tool for the assertion of American cultural vitality on a worldwide scale. America’s ultimate validation, I argue, was established when Cody’s show landed in Italy, ‘the cradle of western civilization’, a stage which exuded a powerful significance in the sphere of culture, and which Cody orchestrated as a symbolic translatio imperii, by picturing himself as a Novel Columbus and America as the vessel of human progress. The resonance of Cody’s Italian tours had a regenerating effect on America; witnessing Italian culture in a moment of profound decadence fostered America’s collective confidence in its cultural superiority and confirmed its newfangled ‘exceptionalism’

Susan Kollin, Captivating Westerns: The Middle East in the American West

Susan Kollin, Captivating Westerns: The Middle East in the American West Lincoln, NE: University of Nebraska Press, 2015. Pp. 294; ISBN 978 0 8032 2699 9. Alessandra Magrin Susan Kollin’s ambitious monograph on the exchanges between the American West and the Middle East in popular culture opens with a fundamental observation: that the Western was “never merely national, but always transnational and global” (35). By overcoming the impasse of a field bound to national narratives for too long, ..

Low plasma PD-L1 levels, early tumor onset and absence of peritoneal carcinomatosis improve prognosis of women with advanced high-grade serous ovarian cancer

BackgroundThe most common subtype of ovarian cancer (OC) showing immunogenic potential is represented by the high-grade serous ovarian cancer (HGSOC), which is characterized by the presence of tumor-infiltrating immune cells able to modulate immune response. Because several studies showed a close correlation between OC patient's clinical outcome and expression of programmed cell death protein-1 or its ligand (PD-1/PD-L1), the aim of our study was to investigate if plasma levels of immunomodulatory proteins may predict prognosis of advanced HGSOC women.Patients and methodsThrough specific ELISA tests, we analyzed plasma concentrations of PD-L1, PD-1, butyrophilin sub-family 3A/CD277 receptor (BTN3A1), pan-BTN3As, butyrophilin sub-family 2 member A1 (BTN2A1), and B- and T-lymphocyte attenuator (BTLA) in one hundred patients affected by advanced HGSOC, before surgery and therapy. The Kaplan-Meier method was used to generate the survival curves, while univariate and multivariate analysis were performed using Cox proportional hazard regression models.ResultsFor each analyzed circulating biomarker, advanced HGSOC women were discriminated based on long (>= 30 months) versus short progression-free survival (PFS < 30 months). The concentration cut-offs, obtained by receiver operating characteristic (ROC) analysis, allowed to observe that poor clinical outcome and median PFS ranging between 6 and 16 months were associated with higher baseline levels of PD-L1 (> 0.42 ng/mL), PD-1 (> 2.48 ng/mL), BTN3A1 (> 4.75 ng/mL), pan-BTN3As (> 13.06 ng/mL), BTN2A1 (> 5.59 ng/mL) and BTLA (> 2.78 ng/mL). Furthermore, a lower median PFS was associated with peritoneal carcinomatosis, age at diagnosis > 60 years or Body Mass Index (BMI) > 25. A multivariate analysis also suggested that plasma concentrations of PD-L1 <= 0.42 ng/mL (HR: 2.23; 95% CI: 1.34 to 3.73; p = 0.002), age at diagnosis <= 60 years (HR: 1.70; 95% CI: 1.07 to 2.70; p = 0.024) and absence of peritoneal carcinomatosis (HR: 1.87; 95% CI: 1.23 to 2.85; p = 0.003) were significant prognostic marker for a longer PFS in advanced HGSOC patients.ConclusionsThe identification of high-risk HGSOC women could be improved through determination of the plasma PD-L1, PD-1, BTN3A1, pan-BTN3As, BTN2A1 and BTLA levels

Prevalence and Spectrum of Germline BRCA1 and BRCA2 Variants of Uncertain Significance in Breast/Ovarian Cancer: Mysterious Signals From the Genome

About 10–20% of breast/ovarian (BC/OC) cancer patients undergoing germline BRCA1/2 genetic testing have been shown to harbor Variants of Uncertain Significance (VUSs). Since little is known about the prevalence of germline BRCA1/2 VUS in Southern Italy, our study aimed at describing the spectrum of these variants detected in BC/OC patients in order to improve the identification of potentially high-risk BRCA variants helpful in patient clinical management. Eight hundred and seventy-four BC or OC patients, enrolled from October 2016 to December 2020 at the “Sicilian Regional Center for the Prevention, Diagnosis and Treatment of Rare and Heredo-Familial Tumors” of University Hospital Policlinico “P. Giaccone” of Palermo, were genetically tested for germline BRCA1/2 variants through Next-Generation Sequencing analysis. The mutational screening showed that 639 (73.1%) out of 874 patients were BRCA-w.t., whereas 67 (7.7%) were carriers of germline BRCA1/2 VUSs, and 168 (19.2%) harbored germline BRCA1/2 pathogenic/likely pathogenic variants. Our analysis revealed the presence of 59 different VUSs detected in 67 patients, 46 of which were affected by BC and 21 by OC. Twenty-one (35.6%) out of 59 variants were located on BRCA1 gene, whereas 38 (64.4%) on BRCA2. We detected six alterations in BRCA1 and two in BRCA2 with unclear interpretation of clinical significance. Familial anamnesis of a patient harboring the BRCA1-c.3367G>T suggests for this variant a potential of pathogenicity, therefore it should be carefully investigated. Understanding clinical significance of germline BRCA1/2 VUS could improve, in future, the identification of potentially high-risk variants useful for clinical management of BC or OC patients and family members

Body mass index and baseline platelet count as predictive factors in Merkel cell carcinoma patients treated with avelumab

BackgroundMerkel cell carcinoma (MCC) is a rare and aggressive skin cancer, associated with a worse prognosis. The Immune Checkpoint Inhibitors (ICIs) avelumab and pembrolizumab have been recently approved as first-line treatment in metastatic MCC (mMCC). The clinical observation of improved outcomes in obese patients following treatment with ICIs, known as the “obesity paradox”, has been studied across many types of tumors. Probably due to the rarity of this tumor, data on mMMC patients are lacking.Patients and methodsThis is an observational, hospital-based, study to investigate the role of Body Mass Index (BMI) as predictive biomarker of ICI response in mMCC patients treated with avelumab as first-line treatment. The study population included the patients treated from February 2019 to October 2022 in an Italian referral center for rare tumors. Clinico-pathological characteristics, BMI, laboratory parameters (NLR and platelet count), and response to avelumab were analyzed from a MCC System database prospectively collected.ResultsThirty-two (32) patients were included. Notably, the presence of pre-treatment BMI ≥ 30 was significantly associated with longer PFS [BMI < 30 Group: median PFS, 4 months (95% CI: 2.5-5.4); BMI ≥ 30 Group: median PFS, not reached; p<0.001)[. Additionally, the median PFS was significantly higher in patients with higher PLT (median PFS: 10 months in the “low PLT” Group (95% CI: 4.9, 16.1) vs 33 months (95% CI: 24.3, 43.2) in the “high PLT” Group (p=0.006). The multivariable Cox regression model confirmed these results.ConclusionTo our knowledge, this is the first study that investigates the predictive role of BMI in MCC patients. Our data were consistent with the clinical observation of improved outcomes in obese patients across other tumor types. Thus, advanced age, a weakened immune system, and the obesity-associated “inflammaging”, are key factors that could impact the cancer immune responses of mMCC patients

Premiers voyageurs italiens à la frontière americaine

This chapter discusses the first Italian travelers to the North American Frontier, little-known sources in the creation of the Wild West myth